The route runs from the Maryland border in the Lewisville section of Elk Township, where it continues as Maryland Route 213, north to Pennsylvania Route 82 in the Doe Run section of West Marlborough Township.
Pennsylvania | University of Pennsylvania | Pennsylvania State University | Pennsylvania Railroad | Harrisburg, Pennsylvania | Pennsylvania House of Representatives | Erie, Pennsylvania | Carlisle, Pennsylvania | Williamsport, Pennsylvania | Scranton, Pennsylvania | West Chester, Pennsylvania | Montgomery County, Pennsylvania | Lancaster, Pennsylvania | Bethlehem, Pennsylvania | U.S. Route 66 | Hershey, Pennsylvania | York, Pennsylvania | U.S. Route 1 | Pennsylvania Turnpike | Pennsylvania Academy of the Fine Arts | Wharton School of the University of Pennsylvania | University Park, Pennsylvania | Wilkes-Barre, Pennsylvania | Johnstown, Pennsylvania | Gettysburg, Pennsylvania | Reading, Pennsylvania | Luzerne County, Pennsylvania | Allentown, Pennsylvania | Abington Township, Montgomery County, Pennsylvania | U.S. Route 6 |