However, AMPK is an enzyme found in many more types of cells than chemoreceptors because it helps regulate metabolism.
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AMPK activation is also a more appealing candidate because it can activate both of the two most common types of potassium channels.
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The difference may actually lie in the cell’s metabolism, rather than the AMPK enzyme; peripheral chemoreceptors display very high background rates of oxygen consumption, supported by its dense network of capillaries.
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Since its base rate of cellular respiration is so high, it’s AMPK would be more sensitive to reductions in blood borne oxygen, thus allowing it to respond to small variations in oxygen content before other cells begin to feel the effects of its absence.
Serial Peripheral Interface Bus | Peripheral neuropathy | Peripheral | Peripheral myelin protein 22 | peripheral chemoreceptors | peripheral |
Normal respiration is driven mostly by the levels of carbon dioxide in the arteries, which are detected by peripheral chemoreceptors, and very little by the oxygen levels.