Soon after Mexico achieved its independence, interest in reopening land communications with Alta California was revived with the arrival of a Dominican missionary, Father Félix Caballero, in Tucson in 1823.
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Casa Blanca was one of the Pima Villages on the Gila River in what was then part of the state of Sonora, Mexico, encountered by the American expeditions of Stephen W. Kearny and Philip St. George Cooke in 1846 and later by Americans on their way to California on the Southern Immigrant Trail during the California Gold Rush.