The player starts out as a human who turned into a Pokémon, which can be one of sixteen Pokémon (Bulbasaur, Squirtle, Charmander, Cyndaquil, Totodile, Chikorita, Treecko, Torchic, Mudkip, Pikachu, Eevee, Machop, Cubone, Psyduck, Meowth, and Skitty) and is determined by a personality quiz taken at the beginning of the game.
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The team meets other rescue teams, including a top-ranked rescue team consisting of Alakazam, Charizard and Tyranitar, named Team ACT.
A 21-minute TV special based on the game starring Kurumi Mamiya aired in Japan on September 9, 2007 as a content of the program relating Pokémon, "Pokémon Sunday" produced by TV Tokyo Corporation.
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Outside of the main series, Slowpoke and Slowbro appear in Pokémon Snap, Pokémon Pinball, Pokémon Trozei!, the Pokémon Mystery Dungeon titles, and Pokémon Rumble.
In 2006, he was a winner of Nintendo of America's "Pokémon Mystery Dungeon" art contest with a tongue-in-cheek cartoon on Franz Kafka's 1915 The Metamorphosis.