The player starts out as a human who turned into a Pokémon, which can be one of sixteen Pokémon (Bulbasaur, Squirtle, Charmander, Cyndaquil, Totodile, Chikorita, Treecko, Torchic, Mudkip, Pikachu, Eevee, Machop, Cubone, Psyduck, Meowth, and Skitty) and is determined by a personality quiz taken at the beginning of the game.
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The team meets other rescue teams, including a top-ranked rescue team consisting of Alakazam, Charizard and Tyranitar, named Team ACT.
Red Army | England national football team | International Red Cross and Red Crescent Movement | American Red Cross | Argentina national football team | Red Hot Chili Peppers | Red Sea | United States men's national soccer team | NYPD Blue | Mexico national football team | Toronto Blue Jays | Brazil national football team | Pokémon | Italy national football team | Blue Peter | Scotland national football team | Germany national football team | Wales national football team | Spain national football team | France national football team | Netherlands national football team | England national rugby union team | Canada men's national soccer team | Belgium national football team | Wales national rugby union team | Red Star Belgrade | Red | New Zealand national rugby union team | The A-Team | New Zealand Māori rugby league team |
A 21-minute TV special based on the game starring Kurumi Mamiya aired in Japan on September 9, 2007 as a content of the program relating Pokémon, "Pokémon Sunday" produced by TV Tokyo Corporation.
Outside of the main series, Slowpoke and Slowbro appear in Pokémon Snap, Pokémon Pinball, Pokémon Trozei!, the Pokémon Mystery Dungeon titles, and Pokémon Rumble.