He became a notary and a person of some importance in the city, and was sent in 1343 on a public errand to Pope Clement VI at Avignon.
Pope Clement VI (1342–1352) — known for being the Pope during the Black Death
At the time of the proclamation, only 38 years had elapsed since the previous Jubilee, which was celebrated under Clement VI.
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On 11 July 1346, in consequence of an alliance between his father and Pope Clement VI, relentless enemy of the emperor Louis IV, Charles was chosen as Roman king in opposition to Louis by some of the prince-electors at Rhens.
At the outbreak of the Great Western Schism, he sided with Pope Clement VI, who made him general prior of the order in September 1379.
Luis de la Cerda, then serving as a French ambassador to the papal court in Avignon, submitted a proposal to Pope Clement VI that offered the Catholic Church the more palatable vision of conquering the islands and converting the native Guanches to Christianity.