HRH Princess Louisa was born on 19 March 1749, at Leicester House, Westminster, London, and was christened there on 11 April.
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She was christened on 27 October 1766 at St James's Palace, by the Archbishop of Canterbury, Thomas Secker, and her godparents were her paternal uncle and aunt, King Christian VII of Denmark and his wife, Caroline Matilda of Great Britain (for whom the Duke of Portland, Lord Chamberlain, and the Dowager Countess of Effingham, stood proxy, respectively) and her paternal aunt, Princess Louisa.