X-Nico

3 unusual facts about Rankl


RANKL

This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor 6 (TRAF6), which indicated this protein may have a role in the regulation of cell apoptosis.

Rankl

Karl Rankl (1898–1968), Austrian-British conductor and composer

RANKL (Receptor activator of nuclear factor kappa-B ligand)


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RANKL | Karl Rankl |

Interferon gamma

IFNγ suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, which otherwise stimulates the production of NF-κB.


see also