Cause normal cells to increase expression of class I MHC molecules as well as class II MHC on antigen presenting cells—specifically through induction of antigen processing genes, including subunits of the immunoproteasome (MECL1, LMP2, LMP7), as well as TAP and ERAAP in addition possibly to the direct upregulation of MHC heavy chains and B2-microglobulin itself
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IFNγ suppresses osteoclast formation by rapidly degrading the RANK adaptor protein TRAF6 in the RANK-RANKL signaling pathway, which otherwise stimulates the production of NF-κB.
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(Equivalent defining cytokines for other cells include IL-4 for Th2 cells and IL-17 for Th17 cells.)
Gamma | Swift Gamma-Ray Burst Mission | Fermi Gamma-ray Space Telescope | Beta Gamma Sigma | Alpha Gamma Rho | The Effect of Gamma Rays on Man-in-the-Moon Marigolds | Sigma Gamma Rho | Pi Gamma Mu | Phi Gamma Delta | Gamma-glutamyl transpeptidase | gamma | The Gamma People | Sigma Tau Gamma | Kappa Kappa Gamma | Gamma wave | Gamma-ray burst | gamma-ray burst | Gamma Phi Beta | Gamma function | Gamma Flight | Erich Gamma | Delta Gamma | The symbol "Gamma | The Effect of Gamma Rays on Man-in-the-Moon Marigolds (film) | Tau Gamma Phi | Sigma Gamma Chi | Omega Gamma Delta | MAGIC (Major Atmospheric Gamma-ray Imaging Cherenkov) | Interferon gamma receptor 2 | Interferon |
In 2000 she made her PhD (with 1st class honours) from Biochemistry and Molecular biology of leukocytic and trophoblastic interferon gamma participating with University of Paris XI, Orsay, France and University of Ljubljana, Medical Faculty, Slovenia.
BRT’s tuberculosis (TB) testing is performed using the Interferon-gamma release assay T-SPOT.TB.
Blood plasma levels of Interleukin 6 (IL-6), Interleukin 8, monocyte chemotactic protein-1 and Interferon-gamma were significantly increased in swine H2N3 compared to human H2N2 infected animals supporting the previously published notion of increased IL-6 levels being a potential marker for severe influenza infections.
IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells.
The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), GM-CSF, and interferon-gamma (IFN-γ).
EPRS is a component of the interferon-gamma-activated inhibitor of translation (GAIT) complex, which interacts with stem-loop elements (GAIT elements) in mRNAs encoding proinflammatory proteins, for example, vascular endothelial growth factor-A (VEGFA).