This variable was discovered by C. Ragoonatha Chary at the Madras Observatory in India.
ER-proteins are degraded in the cytosol by the 26S proteasome, a process known as Endoplasmic-reticulum-associated protein degradation, and therefore have to be transported by an appropriate channel.
endoplasmic reticulum | Endoplasmic reticulum | Endoplasmic-reticulum-associated protein degradation | Endoplasmic Reticulum |
CDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here.
The lacey membranes of the endoplasmic reticulum were first seen in 1945 by Keith R. Porter, Albert Claude, Brody Meskers and Ernest F. Fullam.
In the lysosomal storage disorders Gaucher’s and Tay-Sachs disease, endoplasmic reticulum-associated degradation (ERAD) prevents the native folding of mutated lysosomal enzymes in a patient’s fibroblasts.
RRBP1 (also known as p180), a human gene that encodes a membrane-bound protein of the endoplasmic reticulum.