ER-proteins are degraded in the cytosol by the 26S proteasome, a process known as Endoplasmic-reticulum-associated protein degradation, and therefore have to be transported by an appropriate channel.
protein | Protein subunit | Protein-protein interaction | Hfq protein | protein domain | Protein-protein_interaction | Protein Data Bank | RNA-binding protein | Promyelocytic leukemia protein | G protein | environmental degradation | Wiskott–Aldrich syndrome protein | Protein G | protein dimer | Protein A | endoplasmic reticulum | C-reactive protein | Bone morphogenetic protein 2 | AMP-activated protein kinase | Transmembrane protein | Tau protein | Sterol regulatory element-binding protein | SR protein | Rab escort protein | Protein structure | protein structure | Protein phosphatase 2 | protein kinase | Protein Information Resource | Protein folding |
CDNA sequences are available for several aminopeptidases and a crystal structure of the open state of human endoplasmic reticulum Aminopeptidase 1 ERAP1 is presented here.
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells.
Results from rat hippocampal gene chip data after acute administration of tetrahydrocannabinol (THC) showed an increase in the expression of transcripts encoding myelin basic protein, endoplasmic proteins, cytochrome oxidase, and two cell adhesion molecules: NCAM, and SC1; decreases in expression were seen in both calmodulin and ribosomal RNAs (Kittler et al., 2000).
The lacey membranes of the endoplasmic reticulum were first seen in 1945 by Keith R. Porter, Albert Claude, Brody Meskers and Ernest F. Fullam.
In the lysosomal storage disorders Gaucher’s and Tay-Sachs disease, endoplasmic reticulum-associated degradation (ERAD) prevents the native folding of mutated lysosomal enzymes in a patient’s fibroblasts.
RRBP1 (also known as p180), a human gene that encodes a membrane-bound protein of the endoplasmic reticulum.
This variable was discovered by C. Ragoonatha Chary at the Madras Observatory in India.