Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho.
Rho-GTP, a Rho GTPase, then activates ROCK which phosphorylates other proteins which inhibit neurite outgrowth.
RHOA, the most-studied member of the Rho subclass of the Rho family of GTPases
This particular protein domain can be referred to as a Rho GTPase-activating protein (GAP).
Rho Ventures | Rho | Kappa Delta Rho | Rho, Lombardy | Alpha Gamma Rho | Sigma Gamma Rho | Rho GTPase | Rho railway station | Rho Aquilae | Rac (GTPase) | Rho (letter) | Rho family of GTPases | Pollard's rho algorithm for logarithms | Pollard's rho algorithm | Pollard's rho | Alpha Rho Chi |
The protein is a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases.