Under Bishop Marco Vigerio Della Rovere (1513) the new cathedral was begun in 1540; it was consecrated in 1595 by Pietro Ridolfi (1591), a learned writer.
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That same year, on April 6, he was appointed as the ordinary of the Roman Catholic Diocese of Senigallia in Italy.
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He served as Bishop of Senigallia from 1818 until his death in 1843.