Aicardi–Goutières syndrome (AGS) is a congenital immune-mediated neurodevelopmental disorder caused by mutations in the SAMHD1, TREX1, or Ribonuclease H2 (RNASEH2A, RNASEH2B, RNASEH2C) genes.
Vpx enhances HIV-2 replication in humans by counteracting the host factor SAMHD1.
SAMHD1 |