ERRalpha and PGC-1α are coactivators of both Glucokinase (GK) and SIRT3, binding to an ERRE elements in the GK and SIRT3 promoters.
SIRT3, SIRT4, and SIRT5 are active in mitochondria, the energy-producing organelles that are a part of every cell.
The company later focused on developing more potent synthetic activators of SIRT1 and is investigating SIRT3 as another potential drug target.
SIRT3 |