miR-598 has been shown to directly target and inhibit the Sir2 homolog, silent information regulator one (SRT1) enzyme, in the senescence of human adipose-tissue-derived mesenchymal stem cells.
SIRT3, SIRT4, and SIRT5 are active in mitochondria, the energy-producing organelles that are a part of every cell.
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SIRT7 is active in the nucleolus, a compartment of the nucleus reserved for the assembly of ribosomes.
Sir2 |