It was initially named SM Centerpoint as it is located very near the tripoint of the City of Manila, Quezon City and what was then the municipality of San Juan.
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The station is near landmarks such as the Santa Mesa Public Market, SM City Sta. Mesa, the main campus of the Polytechnic University of the Philippines (PUP), the Eulogio "Amang" Rodriguez Institute of Science and Technology (EARIST), the Sacred Heart of Jesus Catholic School and the Philippine headquarters of the Tzu Chi Foundation.