It flows from the department of Canindeyú, crosses the department of San Pedro just south of the department capital of San Pedro de Ycuamandiyú to join the Paraguay river.
The conquistador Aleixo Garcia, the first European to cross Paraguay and reach the Inca empire in 1524, is believed to have been killed near San Pedro on his return.
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San Pedro was founded on 16 March 1786 by Commander José Ferreira and Captain Pedro García.
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