In 242, the Roman emperor Gordian III set out against the Sasanians with “a huge army and great quantity of gold,” (according to a Sasanian rock relief) and wintered in Antioch, while Shapur was busy in subduing Khwarezm and Gilan.
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Gordian III later invaded eastern Mesopotamia but faced tough resistance from the Sasanians; following this blockade Gordian died in battle and Romans chose Philip the Arab as Emperor.