Today this phenomenon is explained by the overexpression and accumulation of the endogenous lysosomal beta-galactosidase specifically in senescent cells.
Beta | Tau Beta Pi | Phi Beta Sigma | beta | Zeta Beta Tau | TGF beta 1 | Beta Gamma Sigma | The Beta Band | Tau Beta Sigma | Phi Beta Kappa Society | Beta Israel | TGF beta receptor 2 | National Beta Club | Beta (plant) | Beta (letter) | Beta-Hexachlorocyclohexane | Beta Flight | Beta Alpha Psi | VHS or Beta | Steroid 11-beta-hydroxylase | Gamma Phi Beta | Epoetin beta | Beta (typeface) | Beta Sigma Phi | Beta-galactosidase | beta decay | Beta Crucis | Beta Centauri | Beta amyloid | Alpha-Beta |
Some patients have petitioned to break the company's patent on the drug under the "march-in" provisions of the Bayh–Dole Act.
Heparanase cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group.
To engineer JX-594, human GMCSF gene (encoding granulocyte macrophage colony-stimulating factor or GM-CSF; driven by a synthetic early/late promoter) and lacZ gene (encoding β-galactosidase or β-gal; driven by the p7.5 early/late promoter) were inserted into the TK gene (encoding thymidine kinase or TK) in the J segment of the Wyeth strain vaccinia virus.
The enzyme, β-galactosidase, is available in tablet form in a variety of doses, in many countries without a prescription.
miR-598 has been shown to directly target and inhibit the Sir2 homolog, silent information regulator one (SRT1) enzyme, in the senescence of human adipose-tissue-derived mesenchymal stem cells.
While the plant is growing and developing additional leaves, the cotyledons eventually senesce and fall off.