"Shake the Disease" is Depeche Mode's thirteenth UK single recorded at Hansa Mischraum in Berlin (released on 29 April 1985), and was one of two new songs released on the compilation The Singles (81-85) the same year, along with "It's Called a Heart".
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Los Angeles modern rock radio station KROQ-FM named "Shake the Disease" as the number one song of 1985.
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The music video is the first Depeche Mode video directed by Peter Care and features an innovative camera trick to make it appear as though the band members are falling.
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All videos were directed by Clive Richardson except "Shake the Disease" and "It's Called a Heart" which were directed by Peter Care.