He is best known for his English translation of Maimonides' Guide to the Perplexed, which was the most popular such translation until the more recent work of Shlomo Pines, and still remains in print.
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In 1971, a 10th-century Arabic version of the Testimonium due to Agapius of Hierapolis was brought to light by Shlomo Pines who also discovered a 12th-century Syriac version of Josephus by Michael the Syrian.