In December 1798 he was appointed by Lord Mornington, the governor-general, to command the field army which was intended to attack Tipu Sultan, and in a few months of campaigning Harris reduced the Kingdom of Mysore and stormed the great stronghold of Seringapatam, where the Tipu died in its defence.
Numerous memorial-plaques and monuments exist within the church of which two, that of Sir Barry Close, who was Adjutant General to Gen. George Harris at the Siege of Seringapatam, and gave his name to Closepet, and that of Lt. Col. Joseph Moorhouse, who was killed at the Siege of Bangalore, in the Third Anglo-Mysore War, would be of particular interest to the historian.
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In the Fourth Anglo-Mysore War, he allegedly pulled the Mysorean army from the battlefield to collect their salaries, during the Siege of Seringapatam.