In the 1957 novel From Russia, with Love by Ian Fleming, protagonist James Bond fights his enemy, SMERSH-agent Donovan Grant, eventually killing him, while passing through the Simplon Tunnel by Orient Express.
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There is a car-carrying shuttle between Brig and Iselle di Trasquera which provides a 20 minute train journey as an alternative to driving over the Simplon Pass.
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In 1915, nine years after the opening of the Simplon Tunnel, the direct Frasne–Lausanne line, including the Vallorbe railway station, was opened in conjunction with the piercing of the Mont d'Or.