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His father, William Harcourt Isham Mackworth (1806—1872), a younger son of Sir Digby Mackworth, the 3rd Baronet, took the additional surname Dolben after he married Frances, the heiress of Sir John English Dolben, the 4th Baronet.
Like many at James's court, Petre at first trusted Lord Sunderland, but he was also among the first to detect that minister's duplicity and to break with him.
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In 1686, Lord Castlemaine, James's ambassador to Rome, renewed the application, while James urged it forcibly on Ferdinando d'Adda, the papal nuncio in London.