While Downing Street, London, is named after him, Downing College, Cambridge derives its name from his grandson, Sir George Downing, 3rd Baronet.
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His father, William Harcourt Isham Mackworth (1806—1872), a younger son of Sir Digby Mackworth, the 3rd Baronet, took the additional surname Dolben after he married Frances, the heiress of Sir John English Dolben, the 4th Baronet.
Sir George Downing, 2nd Baronet (c. 1656–1711), Teller of the Receipt of the Exchequer
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Sir George Downing, 1st Baronet (1623–1684), Anglo-Irish soldier and diplomat after whom Downing Street in London is named
Pepys was dining with his friend Sir George Downing on November 9, 1666, when the deaf servant had a conversation in sign language with his master, which included news of the Great Fire of London.
He published a large number of declarations and discourses, mostly in Dutch, enumerated in Sibley's biography, and wrote also "A True Relation of the Progress of the Parliament's Forces in Scotland" (1651), Thomason Tracts, Brit.
Sir George Downing, 3rd Baronet, KB (1685–1749) was a politician and, through a donation in his will, the founder of Downing College, Cambridge.