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His father, William Harcourt Isham Mackworth (1806—1872), a younger son of Sir Digby Mackworth, the 3rd Baronet, took the additional surname Dolben after he married Frances, the heiress of Sir John English Dolben, the 4th Baronet.
He named the college after Sir John Evelyn and was able to recruit most of Princeton's most noted faculty members, including Woodrow Wilson and Henry Fine, to teach at the college.
John never married and on his death aged 75 at Bexhill-on-Sea on 14 May 1833, he was succeeded by his only surviving younger brother, Hugh.
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The elder Charles, of Yarlington, Somerset, died aged 40 in January 1748, while the younger Charles died before 1781.