The Society to Encourage Studies at Home was founded in 1873 by Anna Eliot Ticknor (1823–1896), daughter of George Ticknor, historian and Harvard professor.
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Among those involved as teachers were: Ellen Swallow Richards (science), Vida Dutton Scudder (English), Lucretia Crocker (science), Katherine Peabody Loring (history), Alice James (history), Lucy Elliot Keeler (history), Florence Trail (ancient history) and Elizabeth Thorndike Thornton (history).
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Numerous tenants have occupied various parts of the house through the years, including Samuel Dexter, Christopher Gore, John Jeffries, Harrison Gray Otis, Anna Ticknor's Society to Encourage Studies at Home, and temporarily in 1824, Lafayette.