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Isaac Holmes (1758–1812) was an early American politician from South Carolina, serving as the 14th Lieutenant Governor of that State after the Revolution, as well as serving in both the South Carolina House and Senate.
Harry L. Ott, Jr., Russell's father, represented the 93rd district in the South Carolina House of Representatives, but resigned on June 30, 2013, to take a job with the Farm Service Agency.
Long-serving Democratic Congressman John Spratt, in a bid for his thirteenth term, faced a credible challenge from State Representative Ralph Norman.
Solomon Blatt, Sr. (1895–1986), speaker of the South Carolina House of Representatives
His uncle is the former Speaker of the South Carolina House of Representatives, Robert Sheheen.