Arthur Storer, first astronomer in the American colonies and the original namesake for Halley's Comet, lived the latter part of his life in Calvert County.
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In 1912, the Bank of Brandywine was chartered from what had previously been the Southern Maryland German-American Bank.
The royal government that took over the Colony, after moving the founding capital from the Catholic stronghold of St. Mary's City on the shores of the Potomac and Chesapeake in southern Maryland to the more central and re-named Annapolis near Kent Island in 1694; banned Catholics from holding office, bearing arms, serving on juries, and eventually from voting.
Walter Bowie was a major advocate of expanding the railroad system into southern Maryland, and wrote articles lobbying for this under the pen name Patuxent Planter.
Latchford married Marie Leola Spalding, the daughter of Basil William Spalding, a Confederate Civil War hero from southern Maryland.