The conflict between the Spanish King Philip II and the Dutch rebels in the Spanish-ruled Habsburg Netherlands, culminating in the Eighty Years' War, symbolized the prominent European power struggle of the 16th century between Catholics and Protestants.
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Parts of the road were already in use, but it was Philip II of Spain in 1565, who brought it together when he decided to link up his separate territories through a route that travelled through them and neutral territory.
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Vuelta a Andalucía (English: Tour of Andalucía), a regional Spanish road bicycle race