To circumvent this problem, Greg Winter and his colleagues humanised Campath-1, by extracting the hypervariable loops that had specificity for CD52 and grafting them onto a human antibody framework.
They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl.
He carried out his PhD studies with Lionel Crawford in London working on chromatin organisation and DNA sequence specificity using polyoma virus.
Their specificity is for the small GTP-binding proteins RhoA, RhoB, and RhoC, which are ADP-ribosylated on an asparagine residue.
The enzymes for capping can only bind to RNA polymerase II ensuring specificity to only these transcripts, which are almost entirely mRNA.
#Non-specific immunostimulants act irrespective of antigenic specificity to augment immune response of other antigen or stimulate components of the immune system without antigenic specificity, such as adjuvants and non-specific immunostimulators.
In 1988, Jortner was awarded the Wolf Prize in Chemistry along with Raphael David Levine of Hebrew University of Jerusalem for "their incisive theoretical studies elucidating energy acquisition and disposal in molecular systems and mechanisms for dynamical selectivity and specificity".
The presence of other immunoglobulins (especially IgA) and/or complement proteins (especially C4) increases the specificity of a positive test.
Gallatin complained that the bill was badly worded, lacking specificity in certain situations.
Omega-atracotoxin is an insect-specific neurotoxin of Blue mountains funnel-web spiders whose phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels.
a class I PI 3-kinase, a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation
For example, its structure and its specificity differ in humans, Escherichia coli (E. coli), and the parasiteTrypanosoma cruzi.
PCT has the greatest sensitivity (85%) and specificity (91%) for differentiating patients with systemic inflammatory response syndrome (SIRS) from those with sepsis, when compared with IL-2, IL-6, IL-8, CRP and TNF-alpha.
The β (beta) subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity.
She is much more critical however of Harrington's discussion of her primary topic, exclaiming that she "does not do nearly enough to locate the experiences of religious women with specificity" and that as such, readers will turn back to the work of Kathleen Hughes.
Because of its specificity toward proline, it has been suggested that X-prolyl aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby complementing the pancreatic peptidases.