In 1521, the Portuguese navigator and explorer Ferdinand Magellan under the service of Spain came across the Philippines while searching for the Spice Islands.
Grenada, also known as the Island of Spice or the Spice Isle
Sultanate of Tidore (Indonesian: Kesultanan Tidore, sometimes Kerajaan Tidore) was a sultanate in Southeast Asia, centered on the Spice Islands of Tidore, a rival of Sultanate of Ternate for control of the spice trade.
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During the 16th century, the first Europeans in East Asia — the Spanish, from their colony of the Philippines, and the Portuguese, operating out of their base in Malacca (conquered in 1511) — sought trading rights and influence in the Spice Islands, the modern Moluccas or Maluku Islands.