Hallmarks of Alzheimer's disease (AD) are impairment of cognition, aggregation of β-amyloid peptide (Aβ), neurofibrillary degeneration, loss of neurons with accelerated atrophy of specific brain areas, and decrease of synapse number in surviving neurons.
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One specific example is that the gill withdrawal reflex of the Aplysia is caused by homosynaptic depression.
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Conclusions from this study include synaptic fatigue being primarily a presynaptic phenomenon and not being affected by postsynaptic receptor desensitization, synaptic fatigue is not a result of Ca2+ ions building up in the terminal, and most importantly that synaptic fatigue is an important player and can be studied when researching the causes and effects of some neurodegenerative diseases.
Chronic fatigue syndrome | chronic fatigue syndrome | Post-viral fatigue syndrome | International Committee on Aeronautical Fatigue and Structural Integrity | Fatigue Avoidance Scheduling Tool |