In the early 17th century, the town was under the jurisdiccion of neighboring Tlaltenango and was primarily inhabited by indigenous people, though a few Spanish families had begun to settle in the area with the end of the Chichimeca War.
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To the north, it is bordered by the municipality of Tlaltenango de Sánchez Román, to the south by the municipality of Teúl de González Ortega, to the east by the municipalities of Jalpa and Apozol, to the west by the municipalities of Atolinga and Florencia de Benito Juárez as well as the state of Jalisco.
The town of Tlaltenango was entrusted to Toribio de Bolaños, Tepechitlán to Pedro de Bobadilla, a soldier of Nuño Beltrán de Guzmán, and El Teúl was an encomineda of Juan Delgado.