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Films released in 1916 (starring Gillette as Holmes) and 1922 (starring John Barrymore), both titled Sherlock Holmes, were based on the play, as was a 1938 Mercury Theatre on the Air radio adaptation titled The Immortal Sherlock Holmes, starring Orson Welles as Holmes.
Among the other radio shows on which he appeared were The Great Gildersleeve, Lux Radio Theatre, The Screen Guild Theatre, The Mercury Theatre on the Air, and Suspense.
He began with an adaptation of Heart of Darkness, something he had previously adapted for The Mercury Theatre on the Air and The Campbell Playhouse, and which he had attempted to make as his first film in 1940 before turning his attention to Citizen Kane.