Ned Buntline wrote The Mysteries and Miseries of New York in 1848, but the leading American writer in the genre was George Lippard whose best seller was The Quaker City, or The Monks of Monk Hall: a Romance of Philadelphia Life, Mystery and Crime (1844); he went on to found the paper The Quaker City as a vehicle for more of his mysteries and miseries.
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His best-known work was the long-running serial The Mysteries of London (1844), which borrowed liberally in concept from Eugène Sue's Les Mystères de Paris (The Mysteries of Paris).