Noah Inhofer decides to quit the show and return to Yankton, South Dakota after receiving a letter informing him that his girlfriend back home believes he has cheated on her.
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This series of The Ultimate Fighter was also the first in which fighters who reside outside of North America had participated (Michael Bisping, Clitheroe, England; Ross Pointon, Stoke-on-Trent, England).
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The card also saw the return of former Heavyweight Champion Andrei Arlovski and The Ultimate Fighter 3 winner Michael Bisping's first bout in the UFC since winning that season.
The card also featured former heavyweight champion Frank Mir against K-1 veteran Antoni Hardonk; The Ultimate Fighter 3's winner Kendall Grove; the UFC debut of PRIDE veteran Marcus Aurélio; The Ultimate Fighter 2 welterweight winner Joe Stevenson; and former light heavyweight challenger Renato Sobral.