He was the principal political advisor to the prominent New York politician William H. Seward and was instrumental in the presidential nominations of William Henry Harrison (1840), Henry Clay (1844), Zachary Taylor (1848), Winfield Scott (1852), and John Charles Frémont (1856).
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In 1832, Weed supported Adams' ally Henry Clay, who ran for President as a "National Republican".
At the age of seventeen, he became a printer in the office of the Cooperstown Federalist, and in 1813 he was editor of the Herkimer American, with Thurlow Weed as his journeyman.
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Thurlow Weed, (1797–1882), born in Cairo, was a newspaper editor and political boss, who promoted, by turns (and sometimes simultaneously), the National Republican, Anti-Masonic, Whig and Republican parties.
Abbott Lawrence of Massachusetts, who had worked diligently to obtain the Presidential nomination for Zachary Taylor, expected to be the Vice Presidential nominee, counting on the support of Thurlow Weed of New York and the southern delegates who had backed Taylor for the presidential nomination.