The island serves as the player's headquarters in the 2010 action-adventure stealth video game Assassin's Creed: Brotherhood.
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The church is in the rione Sant'Angelo of Rome at the Piazza Gerusalemme, north of Tiber Island at the north end of the Pons Fabricius (Ponte Quattro Capi) and east of the Great Synagogue of Rome (Tempio Maggiore).