In the Papal States, however, in 1465 he eliminated the regime of the counts of Anguillara, a house that had played a consistent anti-papal role since the plot of Stefano Porcari and the unruly insurrection of Tiburzio di Maso in 1460.
In the tumultuous atmosphere of the revolt against Ferrante, the Aragonese King of Naples by the local lords who supported the claims of the House of Anjou, which broke out anew in 1460, Francesco Sforza had induced the Pope, Pius II to support Ferrante in the Neapolitan War of 1460-61.