The river's sources are located between Ecuadorian El Oro and Loja provinces.
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Rivers of both Ecuador and Peru empty in the Gulf of Guayaquil, like the Guayas River, the Jubones River, the Zarumilla River and the Tumbes River.
Morphologically, four zones can be defined in the region: the delta of the Tumbes and Zarumilla rivers; an alluvial plain north of the Tumbes River, with dry, low-depth ravines; ancient terraces that have been strongly eroded in the Máncora area; and the Amotape mountain range in the east and south, ending at El Barco Mountain.