The northern terminus of the highway is located in Aguas Verdes (Tumbes Region) at the border with Ecuador.
Morphologically, four zones can be defined in the region: the delta of the Tumbes and Zarumilla rivers; an alluvial plain north of the Tumbes River, with dry, low-depth ravines; ancient terraces that have been strongly eroded in the Máncora area; and the Amotape mountain range in the east and south, ending at El Barco Mountain.
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As a result Ecuador had to renounce the territories Tumbes, Jaén and Maynas.
The largest towns on its banks are Huaquillas, in the Ecuadorian province of El Oro, and Aguas Verdes in the Tumbes Region of Peru; both towns are connected by an international bridge.