Linkage analysis and chromosomal rearrangement revealed the cause of SCS to be mutations in the TWIST gene (twist transcription factor gene) located on chromosome 7p21.
The O'Reilly Factor | The X Factor (UK) | Microphthalmia-associated transcription factor | The X Factor | Fear Factor | Oliver Twist | Max Factor | Twist and Shout | The X Factor (TV series) | B-cell activating factor | Epidermal growth factor receptor | Round the Twist | Psi Factor: Chronicles of the Paranormal | Phonetic transcription | Astro Boy: Omega Factor | Twist | Lil Twist | A Twist in the Tale (TV series) | twist transcription factor | Twist of Faith | Twist Around the Clock | The X Factor (U.S.) | The X Factor (UK TV series) | The X Factor (UK series 2) | The Omega Factor | The Butch Factor | The Adonis Factor | Sp1 transcription factor | Rheumatoid factor | PSI Factor |
SNAI1/Snail 1, SNAI2/Snail 2 (also known as Slug), ZEB1, ZEB2, E47 and KLF8 (Kruppel-like factor 8) can bind to E-cadherin promoter and repress its transcription, whereas factors such as Twist, Goosecoid, E2.2 (also known as TCF4), homeobox protein SIX1 and FOXC2 (fork-head box protein C2) repress E-cadherin indirectly.
EMT can be induced by a number of genes including Snail, Twist, Goosecoid, and TGF-beta 1.