Monsignor Larrea Holguín was a professor in various Ecuadorian universities, including the Catholic University of Guayaquil of and Central University of Ecuador.
UCSG was created on May 17, 1962, at the request of the board of Catholic college pro presiding Bishop Cesar Antonio Mosquera Corral, Archbishop of Guayaquil, the jurist Dr. Leonidas Ortega Moreira and P. Joachim Flor Vásconez SJ, who were its founding authorities, as Chancellor, first president and director, respectively.
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He created more than 100 murals during his lifetime, many of which can be seen in buildings throughout his hometown, such as the Municipal Museum of Guayaquil, the Social Security Fund Building, the old Simon Bolivar Airport, the Children's Hospital, the Catholic University of Santiago of Guayaquil, Ecuavisa, among others.
Investigators from the Ecuadorian Catholic University (Universidad Católica de Santiago de Guayaquil) (Guayaquil) and the Spanish University of Zaragoza (Zaragoza), performed a comparative study at the Enrique C. Sotomayor Obstetric and Gynecology Hospital (Guayaquil) assessing resilience differences between pregnant adolescents and adults.