Ciglitazone significantly decreases VEGF production by human granulosa cells in an in vitro study, and may potentially be used in ovarian hyperstimulation syndrome.
The latter two (axitinib and pazopanib) are in clinical trials, the results of which were presented (June 7) at the American Society of Clinical Oncology meeting.
The O'Reilly Factor | The X Factor (UK) | Microphthalmia-associated transcription factor | The X Factor | Fear Factor | Max Factor | The X Factor (TV series) | B-cell activating factor | Epidermal growth factor receptor | Psi Factor: Chronicles of the Paranormal | Astro Boy: Omega Factor | The Limits to Growth | growth | Economic growth | twist transcription factor | The X Factor (U.S.) | The X Factor (UK TV series) | The X Factor (UK series 2) | The Omega Factor | The Butch Factor | The Adonis Factor | Sp1 transcription factor | Rheumatoid factor | PSI Factor | population growth | O'Reilly Factor | Insulin-like growth factor 1 | growth hormone | Factor Three | factor |
HIF-1α causes the production of vascular endothelial growth factor, platelet derived growth factor B, erythropoietin and transforming growth factor alpha, which act to stimulate growth of cells within the tumour.
EPRS is a component of the interferon-gamma-activated inhibitor of translation (GAIT) complex, which interacts with stem-loop elements (GAIT elements) in mRNAs encoding proinflammatory proteins, for example, vascular endothelial growth factor-A (VEGFA).