Local anesthetics with vasoconstrictors should not be used in the nose, fingers, toes and penis, because the arteries here are end arteries, so the vasoconstrictor effect could cause ischemia and even gangrene of the affected part.
Prostanoids are a subclass of eicosanoids consisting of the prostaglandins (mediators of inflammatory and anaphylactic reactions), the thromboxanes (mediators of vasoconstriction), and the prostacyclins (active in the resolution phase of inflammation.)