In the video game Darksiders, the Destroyer draws his power from the well of souls which Azrael unwittingly helped him do.
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In Thirdspace, a made-for-TV episode of the science fiction series Babylon 5, the Vorlons attempt to connect with what they believe to be their own Well of Souls by building a special kind of jumpgate.
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In the 1981 film Raiders of the Lost Ark, Tanis was said to be the resting place of the Ark of the Covenant which was hidden in a secret chamber called the Well of Souls.