He was rector until his promotion to the See of Louisville in May 1868, being consecrated bishop in the chapel of the college on May 24 of that year by Cardinal von Reisach, Archbishop of Munich, Bavaria, assisted by Mons.
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He introduced many religious orders into the diocese: the Passionists, the Benedictines, the Fathers of the Resurrection, the Sisters of Mercy, the Little Sisters of the Poor, the Franciscan Sisters, and the Brothers of Mary.
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