Yaakov Yitzchak was a descendant of Isaiah Horowitz (Hebrew: ישעיה הלוי הורוביץ), also known as the Shelah ha-Kadosh (Hebrew: של"ה הקדוש), a prominent Levite rabbi and mystic.
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During his stay in Lublin, Yaakov Yitzchak was opposed by a prominent rabbi, Rabbi Ezriel Horowitz.
Lublin | Yaakov Chaim Sofer | Lublin Ghetto | John Paul II Catholic University of Lublin | Yitzchak Elchanan Spektor | Yaakov Ben-Tor | Nancy Lublin | Lublin Voivodeship | Lublin–Brest Offensive | Fred D. Lublin | Yosef Yitzchak Jacobson | Yitzchak Meir Helfgot | Yitzchak Isaac of Zidichov | Yaakov Yitzchok Ruderman | Yaakov Yitzchak of Lublin | Yaakov Rubinstein | Yaakov Perlow | Yaakov Ne'eman | Wąwolnica, Lublin Voivodeship | Motor Lublin | Modliborzyce, Lublin Voivodeship | Lublin railway station | Lublin (Majdanek) | Lubień, Lublin Voivodeship | Łazy, Lublin Voivodeship | Goraj, Lublin Voivodeship | Czermno, Lublin Voivodeship | Cichy, Lublin Voivodeship | Chaim Yitzchak Bloch Hacohen | Biernat of Lublin |
Famous descendants of Isaiah Horowitz included Yaakov Yitzchak of Lublin, (Yaakov Yitzchak Horowitz; Hebrew: יעקב יצחק הורוביץ), known as "The Chozeh of Lublin" (Hebrew: החוזה מלובלין, The Seer of Lublin), the prominent Billiczer Rabbinical family of Szerencs, Hungary and the Dym family of Rabbis and communal leaders in Galicia.